Skip to main content

Alkylhalides: Introduction

Alkylhalides: an initiation

Background information

Alkylhalides are compounds (in this case salts) that consist of an alkyl group and an halogen (seventh row in the table of Mendeljev). 
Alkylhalides have good leaving groups, these groups are the atoms (or the atom) that will be substituted or eliminated during elimination or substitution reactions on the molecule. This fenomenon is caused by the polar bond formed between the halogen and the alkyl group, making the halogen more afferent to be attacked (substituated / eliminated) by a nucleophile.

Nucleophile substitution reaction (SN2 reaction)

A nucleophile 'attacks' the alkylhalide, the leaving group - in this case the halogen - will be taken of the compound and will be replaced (SUBSTITUTED) by the nucleophile (hense the reaction its name). This reaction however is characterized and depended by several factors including:
  • the solvent in which the reaction is taking place
  • the reactivity or activity of the attacking nucleophile
  • the concentration and amount of added nucleophile
  • the structure and compound of the alkylhalide
Experiments have shown that the Sn2 reaction really takes place by noticing following measures:
  • the configuration of the substituted product is inverted (contrary) to the original reacting chiral configured alkylhalide
  • if the alkylhalide is more branched off at the reaction center, the reaction rate of the attacking nucleophile will go down thus resulting in a much slower reaction (slow tertiary < secondary < primary fast)
  • logic: the reaction rate is dependent on the concentration of both compounds (alkylhalide and nucleophile)




Comments

Popular posts from this blog

Erythropoietin: definition, structure, synthesis in vivo

Definition: EPO: = erythropoietin   A glycoprotein hormon-like structure, a sialoglycoprotein, which is an important factor in the survival, growth and proliferation of erythroid precursor cells (EPC) and it improves the de novo creation, differentation and growth of red blood cells (RBC). Thus, EPO controls the erythropoiesis = production of RBC. EPC: these are cells that are located in the bone marrow, will eventually form the RBC. RBC: cells responsible for the transport and distribution of oxygen throughout the body. Structure: Built out of 165 aminoacids (AA). They are all connected and form 1 polypeptide chain.  Although, within the chain, there are 2 disulfide bonds.  Respectively on positions: Cys7-161 and Cys29-33  Cys = cystein and the numbers indicate the positions these AA are located. Cystein structure. Available  sulfide  group for bonding There are also 4 positions where there is a possibility for glycosylation  Namel...

Coca-Cola: Life - myth or truth?

"Coca-Cola Life" Recently the Coca-Cola company released a new beverage: the Coca-Cola Life drink. It should contain less sugar than the normal Coca-Cola drink; a part of the sugar is replaced with the recently approved sweetener from the Stevia plant (stevioglycosides). It's being sold as a 'natural' drink, but those stevioglycosides are as natural as the chemical sweetener aspartame found in Light and Zero drinks. However it is true that the amount of sugar is much lower (being reported as 33%, some say it's around 20%); yet approximately still 3-4 sugar cubes / 33 cl can (5-6 in a normal can). I bought it myself and found that the flavor has not really changed from the original Coca-Cola, however it does taste more "flat" - but definitely true it yourself. The outside of the can has the colour green. I personally do not associate this "healthy - natural" colour with Coca-Cola, but it's growing on me. In sum...

Alkynen: Elektrofiele additie

Elektrofiele additie: Waterstofhaliden op alkynen Voorbeeld van waterstofhaliden: HCl, HBr, HF, HI Gebruik van één equivalent waterstofhalide met alkyn (dus 1:1 geen overmaat geen tekort) Bij een overmaat aan het waterstofhalide zal een tweede reactie plaatsvinden op het gehalogeneerde alkyn, ter vorming van een geminaal regioisomeer.