Skip to main content

How to use: Spiriva Handihaler®

Spiriva Handihaler® consists of the anticholinergic drug tiotropiumbromide. This medicin is used in the treatment of chronic obstructive pulmonary diseases, most often abbreviated as COPD.

Pharmacology: tiotropiumbromide is a long-acting anticholinergic drug. It blocks the muscarin receptor. This way, the neurotransmitter acetylcholine will not be able to bind on this receptor. The result is a relaxation of the bronchialic muscle tissue.

Always use this medication as your doctor/pharmacist advises you. The most commonly used therapy is the inhalation of one capsule a day, on the same hour each day.

How to use the Handihaler:
Step 1: It may sound logical, but open the cap and the mouth piece.



Step 2:
Gently take a Spiriva capsule. Place it in the open space. Close it off with the mouth piece until you hear a soft click. Press the green button FULLY on the side only once. By pressing this button, the capsule will be "pierced", creating small openings in the capsule, ready to inhale.



Step 3:
- Fully breath out as much as possible. Note: away from the Handihaler! We do not want the Handihaler to be humidified by the breath.
- Place yourself in a straight position, tilt your head a little bit backwards (this will open up the lungs, and this will prevent the drug to be stuck in the throat.
- Place your mouth on the mouth piece: place it between the teeths and enclose it with your lips.
- Breath in as hard as you can! Not through the nose however, watch out with that. While breathing in, you will hear a small zooming sound. This is the capsule spinning, making it possible to extract the drug out.
- Remove the Handihaler from the mouth. Try to keep in your breath for 5-10 seconds. Then, breath out slowly.

Repeat step 3 a second time: this will make sure all medicin is inhaled.

Step 4:
- Close off the Handihaler with the protection cap.
- Rinse your mouth with water! If a small fraction of tiotropium is left in the mouth, this could give a dry mouth, with possible complications. Always make sure to rinse your mouth with water after EVERY application.


Comments

Popular posts from this blog

Alkynen: Elektrofiele additie

Elektrofiele additie: Waterstofhaliden op alkynen Voorbeeld van waterstofhaliden: HCl, HBr, HF, HI Gebruik van één equivalent waterstofhalide met alkyn (dus 1:1 geen overmaat geen tekort) Bij een overmaat aan het waterstofhalide zal een tweede reactie plaatsvinden op het gehalogeneerde alkyn, ter vorming van een geminaal regioisomeer.

Coca-Cola: Life - myth or truth?

"Coca-Cola Life" Recently the Coca-Cola company released a new beverage: the Coca-Cola Life drink. It should contain less sugar than the normal Coca-Cola drink; a part of the sugar is replaced with the recently approved sweetener from the Stevia plant (stevioglycosides). It's being sold as a 'natural' drink, but those stevioglycosides are as natural as the chemical sweetener aspartame found in Light and Zero drinks. However it is true that the amount of sugar is much lower (being reported as 33%, some say it's around 20%); yet approximately still 3-4 sugar cubes / 33 cl can (5-6 in a normal can). I bought it myself and found that the flavor has not really changed from the original Coca-Cola, however it does taste more "flat" - but definitely true it yourself. The outside of the can has the colour green. I personally do not associate this "healthy - natural" colour with Coca-Cola, but it's growing on me. In sum...

Alkylhalides: Substitution reactions 6 (Sn1)

Alkylhalides: Substitution Nucleophile substitution reaction ( Sn1 reaction ) Sn1 side reactions I will now discuss some side reactions that can occur when a Sn1 reaction takes place. Carbocation shift Illustrated in the scheme below: Benzyl- and allylhalides  Benzyl- and allylhalides can undergo Sn1 AND Sn2 reactions. How to distinct them? Sn1 conditions: protic solvent and by adding a weak attacking nucleophile. Note: Benzyl- and allylhalides easily undergo Sn1 reactions, because their carbocations are very stable. Sn2 conditions: aprotic solvent and by adding a strong attacking nucleophile. Note: tertiary benzylhalides and tertiary allylhalides will NOT undergo a Sn2 reaction because of the steric effects (see chapter Sn2 reaction blogposts). Sn2 reaction examples Sn1 reaction examples Sn1 and Sn2 reactions in biology, nature and medicines S-Adenosyl methionine This is a biological methylating agens, also known as SAM . It is a frequen...